Hydrochloric Acid → HCID 70856015, compound

Participants

Reaction Steps

tert-Butyl [6-(2-{(1S,2R)-2-[1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl]cyclopropyl}ethoxy)-5-methylpyridin-3-yl]acetate (380 mg, 0.89 mmol) was treated with 3 mL of HCl (4M in dioxane) and 2 mL of water for 2 hrs at 40° C., then overnight at room temperature. The removal of the volatiles in vacuo gave the crude product which was then used for next step. LCMS (ESI) m/z 429 [M+H]+.

Provenance & Evidence