Hydrochloric Acid → HCID 70856015, compound

HRID 1850801Notes

Reaction equation

HRID 1850801 reaction equation
[CH:1]([C:4]1[N:8]=[C:7]([N:9]2[CH2:14][CH2:13][CH:12]([C@H:15]3[CH2:17][C@H:16]3[CH2:18][CH2:19][O:20][C:21]3[N:26]=[CH:25][C:24]([CH2:27][C:28]([O:30]C(C)(C)C)=[O:29])=[CH:23][C:22]=3[CH3:35])[CH2:11][CH2:10]2)[O:6][N:5]=1)([CH3:3])[CH3:2].Cl>O>[CH:1]([C:4]1[N:8]=[C:7]([N:9]2[CH2:14][CH2:13][CH:12]([C@H:15]3[CH2:17][C@H:16]3[CH2:18][CH2:19][O:20][C:21]3[N:26]=[CH:25][C:24]([CH2:27][C:28]([OH:30])=[O:29])=[CH:23][C:22]=3[CH3:35])[CH2:11][CH2:10]2)[O:6][N:5]=1)([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70856308HCID 70856308, compound

Product 1

HCID 70856015HCID 70856015, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

tert-Butyl [6-(2-{(1S,2R)-2-[1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl]cyclopropyl}ethoxy)-5-methylpyridin-3-yl]acetate (380 mg, 0.89 mmol) was treated with 3 mL of HCl (4M in dioxane) and 2 mL of water for 2 hrs at 40° C., then overnight at room temperature. The removal of the volatiles in vacuo gave the crude product which was then used for next step. LCMS (ESI) m/z 429 [M+H]+.

Workup

  1. customovernight
  2. customat room temperature
  3. customThe removal of the volatiles in vacuo

Sources & evidence

ORD record
ord-67974b8a2ff442319f53ecf7053abd9e
Source dataset
uspto-grants-2015_02
Patent number
US08957062B2

Reaction notes

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