1-(p-Chlorophenyl)cyclobutanecarboxylic acid → 2-({1-[1-(4-Chlorophenyl)cyclobutyl]-4,4-dimethyl-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine

Participants

Role	Name	HCID	Charge
Reactant	1-(p-Chlorophenyl)cyclobutanecarboxylic acid	HCID 602761	—
Reactant	2-(4-Methoxyphenyl)-2-methylpropan-1-amine	HCID 3581364	—
Reactant	1-(4-Fluorophenyl)cyclobutanecarboxylic acid	HCID 16769017	—
Reactant	2-({1-[1-(4-Fluorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine	HCID 58246324	—
Product	2-({1-[1-(4-Chlorophenyl)cyclobutyl]-4,4-dimethyl-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine	HCID 58246302	—

Reaction Steps

2-({1-[1-(4-Chlorophenyl)cyclobutyl]-4,4-dimethyl-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine was prepared analogously to 2-({1-[1-(4-fluorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine (cf. example 65) using 2-(4-methoxyphenyl)-2-methylpropan-1-amine and 1-(4-chlorophenyl)cyclobutanecarboxylic acid in place of 2-(4-methoxyphenyl)ethanamine and 1-(4-fluorophenyl)cyclobutanecarboxylic acid, respectively.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08957089B2
Source dataset	uspto-grants-2015_02
ORD ID	ord-6e8e71afa12b4646a18c76613196a50f
Source note	uspto-grants-2015_02