反应详情

1-Propylamine (314 mg, 5.31 mmol) was dissolved in dichloromethane (3 mL) and a solution of 3-({1-[1-(4-chlorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-yl}oxy)propane-1-sulfonyl chloride (200 mg, 0.442 mmol) in dichloromethane (2 mL) was added dropwise. After 1 h stirring at room temperature the reaction mixture was diluted with dichloromethane (10 mL) and was washed with aqueous ammonium chloride solution (2×) and water (1×), dried (MgSO4) and concentrated in vacuo. The crude product (265 mg) was used for the next step without purification.

1. washwas washed with aqueous ammonium chloride solution (2×) and water (1×)
2. dry with materialdried (MgSO4)
3. concentrationconcentrated in vacuo
4. customThe crude product (265 mg) was used for the next step without purification