Hydrochloric Acid → HCID 66869229, compound

HRID 1850876Notes

Reaction equation

HRID 1850876 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][O:10][C:11]1[CH:20]=[C:19]2[C:14]([CH2:15][CH2:16][N:17]=[C:18]2[C:21]2([C:24]3[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=3)[CH2:23][CH2:22]2)=[CH:13][CH:12]=1)(C)(C)C.Cl>COC>[ClH:30].[Cl:30][C:27]1[CH:26]=[CH:25][C:24]([C:21]2([C:18]3[C:19]4[C:14](=[CH:13][CH:12]=[C:11]([O:10][CH2:9][CH2:8][NH2:7])[CH:20]=4)[CH2:15][CH2:16][N:17]=3)[CH2:22][CH2:23]2)=[CH:29][CH:28]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86653003HCID 86653003, compound

Product 1

HCID 66869229HCID 66869229, compound

Reagents, catalysts & solvents 1

HCID 8254Dimethyl EtherSolvent

Procedure

A solution of tert-butyl[2-({1-[1-(4-chlorophenyl)cyclopropyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethyl]carbamate (440 mg, 1 mmol) methylenehloride (10 ml) was treated with 5N HCl in dimethylether (0.5 ml) and stirred over night at room temperature. The solvent was removed, the residue triturated with diisopropyl ether and the insoluble slid collected. Yield: 370 mg (0.98 mmol, 98%)

Workup

  1. customThe solvent was removed
  2. customthe residue triturated with diisopropyl ether
  3. customthe insoluble slid collected

Sources & evidence

ORD record
ord-40a5f223b2ea4b449bdff6a39788c3ab
Source dataset
uspto-grants-2015_02
Patent number
US08957089B2

Reaction notes

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