HCID 10374990, compound → Pyrrolo[1,2-b]pyridazin-4(1H)-one
Reaction equation
[O:1]=[C:2]1[C:7](C(O)=O)=[CH:6][NH:5][N:4]2[CH:11]=[CH:12][CH:13]=[C:3]12>CS(C)=O>[NH:5]1[CH:6]=[CH:7][C:2](=[O:1])[C:3]2=[CH:13][CH:12]=[CH:11][N:4]12Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 150 °C
Procedure
4-oxo-1,4-dihydropyrrolo[1,2-b]pyridazine-3-carboxylic acid was dissolved in dimethyl sulfoxide (110 mL) and heated at 150° C. for 1 hour. After removing the solvent by distillation under reduced pressure, the resulting residue was purified by silica gel chromatography (5% ethyl acetate in dichloromethane) to give the target compound (5.3 g, 39.5 mmol, 74% yield).
Workup
- customAfter removing the solvent
- distillationby distillation under reduced pressure
- customthe resulting residue was purified by silica gel chromatography (5% ethyl acetate in dichloromethane)
Sources & evidence
- ORD record
- ord-ae050f8e445444299fdd70b5dd697c43
- Source dataset
- uspto-grants-2015_02
- Patent number
- US08957102B2
Reaction notes
Loading…