HCID 10374990, compound → Pyrrolo[1,2-b]pyridazin-4(1H)-one

Participants

Reaction Conditions

Reaction Steps

4-oxo-1,4-dihydropyrrolo[1,2-b]pyridazine-3-carboxylic acid was dissolved in dimethyl sulfoxide (110 mL) and heated at 150° C. for 1 hour. After removing the solvent by distillation under reduced pressure, the resulting residue was purified by silica gel chromatography (5% ethyl acetate in dichloromethane) to give the target compound (5.3 g, 39.5 mmol, 74% yield).

Provenance & Evidence