Triethylamine → HCID 58368389, compound

Participants

Reaction Steps

Pyrrolo[1,2-b]pyridazin-4(1H)-one (2.0 g, 14.9 mmol) and t-butyldimethylsilyl chloride (2.7 g, 17.9 mmol) were dissolved in anhydrous toluene under nitrogen atmosphere. After adding triethylamine (3.1 mL, 22.4 mmol), the mixture was stirred for 1 hour under reflux. Upon completion of the reaction, the produced solid was filtered and washed with a small volume of toluene. The filtrate was concentrated by distillation under reduced pressure. The resulting residue was subjected to the next step without further purification.

Provenance & Evidence