Triethylamine → HCID 58368389, compound

HRID 1851085Notes

Reaction equation

HRID 1851085 reaction equation
[NH:1]1[CH:6]=[CH:5][C:4](=[O:7])[C:3]2=[CH:8][CH:9]=[CH:10][N:2]12.[Si:11](Cl)([C:14]([CH3:17])([CH3:16])[CH3:15])([CH3:13])[CH3:12].C(N(CC)CC)C>C1(C)C=CC=CC=1>[Si:11]([O:7][C:4]1[C:3]2[N:2]([CH:10]=[CH:9][CH:8]=2)[N:1]=[CH:6][CH:5]=1)([C:14]([CH3:17])([CH3:16])[CH3:15])([CH3:13])[CH3:12]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 28928tert-Butyldimethylsilyl chlorideHCID 57415871Pyrrolo[1,2-b]pyridazin-4(1H)-one

Product 1

HCID 58368389HCID 58368389, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Pyrrolo[1,2-b]pyridazin-4(1H)-one (2.0 g, 14.9 mmol) and t-butyldimethylsilyl chloride (2.7 g, 17.9 mmol) were dissolved in anhydrous toluene under nitrogen atmosphere. After adding triethylamine (3.1 mL, 22.4 mmol), the mixture was stirred for 1 hour under reflux. Upon completion of the reaction, the produced solid was filtered and washed with a small volume of toluene. The filtrate was concentrated by distillation under reduced pressure. The resulting residue was subjected to the next step without further purification.

Workup

  1. temperatureunder reflux
  2. customUpon completion of the reaction
  3. filtrationthe produced solid was filtered
  4. washwashed with a small volume of toluene
  5. concentrationThe filtrate was concentrated by distillation under reduced pressure
  6. customThe resulting residue was subjected to the next step without further purification

Sources & evidence

ORD record
ord-698a8904124947fc94c470e6c3640a4d
Source dataset
uspto-grants-2015_02
Patent number
US08957102B2

Reaction notes

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