反应详情

10.2 g (81.9 mmol) 5-Cyclopropyl-1,2,4-triazole-3-ylamine, 25 g (98.3 mmol) diethyl (4-fluorophenyl)malonate and 32.2 mL (135.2 mmol) tributylamine are stirred at 180° C. for 18 hours. The solution is diluted with 120 mL 2N NaOH solution and 120 mL water and the resulting mixture is extracted three times with methyl-tert. butylether. These organic extracts are discarded. The aqueous phase is acidified to pH 1 with 2N HCl. The precipitate is collected by filtration, washed with plenty of water and dried. This material (13.5 g=57.6%) is used without further purification.

1. extractionthe resulting mixture is extracted three times with methyl-tert. butylether
2. filtrationThe precipitate is collected by filtration
3. washwashed with plenty of water
4. customdried
5. customThis material (13.5 g=57.6%) is used without further purification