HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1851179Generated: October 26, 2026
Potassium Carbonate → 4-(6-Phenyl-3-vinylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde
https://huagongshe.com/reaction/1851179
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Tributylvinyltin | HCID 81998 | — |
| Reactant | 4-(3-Bromo-6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde | HCID 86630658 | — |
| Catalyst | Tetraethylammonium Chloride | HCID 5946 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(6-Phenyl-3-vinylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde | HCID 86630663 | — |
Reaction Steps
500 mg 4-(3-bromo-6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde, 180 mg K2CO3, 215 mg Et4NCl, 25 mg PdCl2(PPh3)2 and 620 mg tributyl(vinyl)stannane were suspended in 10 mL THF. The mixture was heated to 110° C. for 45 min. This mixture was worked up by diluting with water and extraction with dichloromethane. The organic layers were dried over Na2SO4 and concentrated to yield the crude product, which was purified by chromatography on silica gel (ethyl acetate/dichloromethane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08957064B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-1417b05f91f949dba3f916dc9bc8bfbd |
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| Source note | uspto-grants-2015_02 |
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