Guanidine Hydrochloride → HCID 68463935, compound

HRID 1851183Notes

Reaction equation

HRID 1851183 reaction equation
[CH3:1][O:2][CH:3]([O:23][CH3:24])[C:4]1[CH:9]=[CH:8][C:7]([C:10](=O)[C:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:12]N(C)C)=[CH:6][CH:5]=1.Cl.[NH2:26][C:27]([NH2:29])=[NH:28].C[O-].[Na+]>CO>[CH3:24][O:23][CH:3]([O:2][CH3:1])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:11]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)=[CH:12][N:26]=[C:27]([NH2:29])[N:28]=2)=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 5742Guanidine HydrochlorideHCID 10942334Sodium MethoxideHCID 68462393HCID 68462393, compound

Product 1

HCID 68463935HCID 68463935, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5 g of the product of step 3 and 3 g guanidine hydrochloride were dissolved in 100 mL methanol and 2.7 g of NaOMe was added. The mixture was heated to reflux for 17 h. The product was precipitated upon dilution of the mixture with water and was collected by filtration and washed twice with water.

Workup

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 17 h
  3. customThe product was precipitated upon dilution of the mixture with water
  4. filtrationwas collected by filtration
  5. washwashed twice with water

Sources & evidence

ORD record
ord-5e2e42341e3c4d40897159613592f8fb
Source dataset
uspto-grants-2015_02
Patent number
US08957064B2

Reaction notes

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