反应详情

A solution of 5.00 g 3-amino-5-ethyl-1,2,4-triazole and 15.00 g diethyl phenylmalonate in 18 mL N,N-dibutylbutan-1-amine was stirred at 185° C. over night. The solution was diluted with 5N NaOH solution, the resulting mixture was stirred for 30 min. The aqueous layer was washed with diethylether, acidified at 0° C. with concentrated HCl until precipitation of the product was complete. The precipitate was collected by filtration to yield the product, which was used without further purification.

1. washThe aqueous layer was washed with diethylether
2. customacidified at 0° C. with concentrated HCl until precipitation of the product
3. filtrationThe precipitate was collected by filtration
4. customto yield the product, which
5. customwas used without further purification