HCID 178498471, compound → Methyl 5-amino-1H-pyrazole-3-carboxylate

HRID 1851230Notes

Reaction equation

HRID 1851230 reaction equation
[N+:1]([C:4]1[CH:8]=[C:7]([C:9]([O:11][CH3:12])=[O:10])[NH:6][N:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:8]=[C:7]([C:9]([O:11][CH3:12])=[O:10])[NH:6][N:5]=1

Participants

4

Reactant 1

HCID 178498471HCID 178498471, compound

Product 1

HCID 18445864Methyl 5-amino-1H-pyrazole-3-carboxylate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To 14.0 g methyl 3-nitro-1H-pyrazole-5-carboxylate in 200 mL methanol were added 1.2 g Pd/C (10% w/w). The mixture was stirred under H2-atmosphere at room temperature for 18 h. The mixture was filtered through Celite. The filtrate was concentrated and the crude product was used without further purification.

Workup

  1. filtrationThe mixture was filtered through Celite
  2. concentrationThe filtrate was concentrated
  3. customthe crude product was used without further purification

Sources & evidence

ORD record
ord-81fc562003f548ffa06cdd3904f5e467
Source dataset
uspto-grants-2015_02
Patent number
US08957064B2

Reaction notes

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