4-(6-Phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde → 1-[4-(6-Phenylimidazo[1,2-a]pyrimidin-7-yl)phenyl]ethanol

関与物質

反応条件

反応手順

100 mg 4-(6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde (prepared as described for example 1) were dissolved in 2 mL THF and 1 mL of a 2M solution of MeZnCl was added. The mixture was heated (100° C., microwave) for 2 h, cooled to room temperature and extracted with a mixture of dichloromethane and water. The organic layers were dried over sodium sulphate and the solvent was evaporated. The crude product was purified by chromatography on silica gel (dichloromethane/ethyl acetate)

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