反应详情

温度

100 °C

100 mg 4-(6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde (prepared as described for example 1) were dissolved in 2 mL THF and 1 mL of a 2M solution of MeZnCl was added. The mixture was heated (100° C., microwave) for 2 h, cooled to room temperature and extracted with a mixture of dichloromethane and water. The organic layers were dried over sodium sulphate and the solvent was evaporated. The crude product was purified by chromatography on silica gel (dichloromethane/ethyl acetate)

1. temperaturecooled to room temperature
2. extractionextracted with a mixture of dichloromethane and water
3. dry with materialThe organic layers were dried over sodium sulphate
4. customthe solvent was evaporated
5. customThe crude product was purified by chromatography on silica gel (dichloromethane/ethyl acetate)