Phosphorus tribromide → 7-[4-(1-Bromoethyl)phenyl]-6-phenylimidazo[1,2-a]pyrimidine
Reaction equation
[C:1]1([C:7]2[C:8]([C:16]3[CH:21]=[CH:20][C:19]([CH:22](O)[CH3:23])=[CH:18][CH:17]=3)=[N:9][C:10]3[N:11]([CH:13]=[CH:14][N:15]=3)[CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P(Br)(Br)[Br:26]>ClCCl>[Br:26][CH:22]([C:19]1[CH:20]=[CH:21][C:16]([C:8]2[C:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[CH:12][N:11]3[CH:13]=[CH:14][N:15]=[C:10]3[N:9]=2)=[CH:17][CH:18]=1)[CH3:23]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
100 mg of the product of step 1 were dissolved in dichloromethane, cooled to 0° C. and 86 mg PBr3 were added. The mixture was stirred at room temperature for 24 h. Ice was added, the mixture extracted with dichloromethane and water, the organic layer were dried over Na2SO4 and the solvent was evaporated. The crude product may be used without further purification.
Workup
- additionIce was added
- extractionthe mixture extracted with dichloromethane and water
- dry with materialthe organic layer were dried over Na2SO4
- customthe solvent was evaporated
- customThe crude product may be used without further purification
Sources & evidence
- ORD record
- ord-230bec2cac9f400091bd867026443b41
- Source dataset
- uspto-grants-2015_02
- Patent number
- US08957064B2
Reaction notes
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