HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1851238Generated: October 26, 2026
Phosphorus tribromide → 7-[4-(1-Bromoethyl)phenyl]-6-phenylimidazo[1,2-a]pyrimidine
https://huagongshe.com/reaction/1851238
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | 1-[4-(6-Phenylimidazo[1,2-a]pyrimidin-7-yl)phenyl]ethanol | HCID 68459225 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7-[4-(1-Bromoethyl)phenyl]-6-phenylimidazo[1,2-a]pyrimidine | HCID 68461086 | — |
Reaction Steps
100 mg of the product of step 1 were dissolved in dichloromethane, cooled to 0° C. and 86 mg PBr3 were added. The mixture was stirred at room temperature for 24 h. Ice was added, the mixture extracted with dichloromethane and water, the organic layer were dried over Na2SO4 and the solvent was evaporated. The crude product may be used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08957064B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-230bec2cac9f400091bd867026443b41 |
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| Source note | uspto-grants-2015_02 |
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