Hydrochloric Acid → HCID 68753946, compound

HRID 1851246Notes

Reaction equation

HRID 1851246 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[N:12]=[C:11]([CH:13]3[CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14]3)[NH:10][N:9]=2)[CH:5]=[CH:4][CH:3]=1.[ClH:24]>O1CCOCC1>[ClH:24].[ClH:24].[NH:15]1[CH2:16][CH:13]([C:11]2[NH:10][N:9]=[C:8]([C:6]3[CH:5]=[CH:4][CH:3]=[C:2]([CH3:1])[N:7]=3)[N:12]=2)[CH2:14]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86702386HCID 86702386, compound

Product 1

HCID 68753946HCID 68753946, compoundYield 76.6%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

11.6 g (36.8 mmol) tert-Butyl 3-[3-(6-methylpyridine-2-yl)-1H-1,2,4-triazole-5-yl]azetidine-1-carboxylate are dissolved in 150 mL dioxane. 27.6 mL HCl in dioxane (4M) are added dropwise and the reaction mixture is stirred over night at room temperature. The reaction mixture is evaporated to dryness yielding 13.1 g (76.6%) of the desired salt which is 60% pure and is used without further purification.

Workup

  1. customThe reaction mixture is evaporated to dryness

Sources & evidence

ORD record
ord-62690b56809448f288d7c43f67ce7d2f
Source dataset
uspto-grants-2015_02
Patent number
US08957064B2

Reaction notes

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