Hydrochloric Acid → HCID 178478943, compound

HRID 1851248Notes

Reaction equation

HRID 1851248 reaction equation
[F:1][C:2]1[CH:16]=[CH:15][C:5]2[NH:6][C:7]([CH:9]3[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]3)=[N:8][C:4]=2[CH:3]=1.[ClH:17]>CO.O1CCOCC1>[ClH:17].[F:1][C:2]1[CH:16]=[CH:15][C:5]2[NH:6][C:7]([CH:9]3[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]3)=[N:8][C:4]=2[CH:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 1785054646-Fluoro-2-(piperidin-4-yl)-1H-benzimidazole

Product 1

HCID 178478943HCID 178478943, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

Thus, 10 g of the crude 5-fluoro-2-piperidin-4-yl-1H-benzoimidazole was dissolved in MeOH (85 mL) and a solution of HCl in dioxane (20 mL) was added dropwise, and the title compound was obtained by filtration.

Sources & evidence

ORD record
ord-34595778a70a41d4b2f49dc6d92c7ab0
Source dataset
uspto-grants-2015_02
Patent number
US08957064B2

Reaction notes

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