2-Piperidin-4-yl-1h-benzoimidazole-5-carbonitrile hydrochloride salt → 2-{1-[4-(6-Phenyl-imidazo[1,2-a]pyrimidin-7-yl)-benzyl]-piperidin-4-yl}-3H-benzimidazole-5-carbonitrile

HRID 1851261Notes

Reaction equation

HRID 1851261 reaction equation
[C:1]1([C:7]2[C:8]([C:16]3[CH:23]=[CH:22][C:19]([CH:20]=O)=[CH:18][CH:17]=3)=[N:9][C:10]3[N:11]([CH:13]=[CH:14][N:15]=3)[CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH:25]1[CH2:30][CH2:29][CH:28]([C:31]2[NH:32][C:33]3[CH:39]=[C:38]([C:40]#[N:41])[CH:37]=[CH:36][C:34]=3[N:35]=2)[CH2:27][CH2:26]1>>[C:1]1([C:7]2[C:8]([C:16]3[CH:23]=[CH:22][C:19]([CH2:20][N:25]4[CH2:26][CH2:27][CH:28]([C:31]5[NH:32][C:33]6[CH:39]=[C:38]([C:40]#[N:41])[CH:37]=[CH:36][C:34]=6[N:35]=5)[CH2:29][CH2:30]4)=[CH:18][CH:17]=3)=[N:9][C:10]3[N:11]([CH:13]=[CH:14][N:15]=3)[CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 687529322-Piperidin-4-yl-1h-benzoimidazole-5-carbonitrile hydrochloride saltHCID 866306554-(6-Phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde

Product 1

HCID 687534042-{1-[4-(6-Phenyl-imidazo[1,2-a]pyrimidin-7-yl)-benzyl]-piperidin-4-yl}-3H-benzimidazole-5-carbonitrileYield 78.1%

Procedure

150 mg (0.5 mmol) 4-(6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde described in example 1 and 136 mg (0.6 mmol) 2-piperidine-4-yl-3H-benzimidazole-5-carbonitrile hydrochloride salt were reacted and purified as described in example 6.0. 199 mg of the desired compound were obtained.

Workup

  1. customwere reacted
  2. custompurified

Sources & evidence

ORD record
ord-594037ab7f85497293cc8836594253fd
Source dataset
uspto-grants-2015_02
Patent number
US08957064B2

Reaction notes

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