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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1851261Generated: November 1, 2026

2-Piperidin-4-yl-1h-benzoimidazole-5-carbonitrile hydrochloride salt → 2-{1-[4-(6-Phenyl-imidazo[1,2-a]pyrimidin-7-yl)-benzyl]-piperidin-4-yl}-3H-benzimidazole-5-carbonitrile

https://huagongshe.com/reaction/1851261

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Piperidin-4-yl-1h-benzoimidazole-5-carbonitrile hydrochloride saltHCID 68752932—
Reactant4-(6-Phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehydeHCID 86630655—
Product2-{1-[4-(6-Phenyl-imidazo[1,2-a]pyrimidin-7-yl)-benzyl]-piperidin-4-yl}-3H-benzimidazole-5-carbonitrileHCID 6875340478.1%

Reaction Steps

150 mg (0.5 mmol) 4-(6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde described in example 1 and 136 mg (0.6 mmol) 2-piperidine-4-yl-3H-benzimidazole-5-carbonitrile hydrochloride salt were reacted and purified as described in example 6.0. 199 mg of the desired compound were obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08957064B2
Source datasetuspto-grants-2015_02
ORD IDord-594037ab7f85497293cc8836594253fd
Source noteuspto-grants-2015_02