HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Piperidin-4-yl-1h-benzoimidazole-5-carbonitrile hydrochloride salt → 2-{1-[4-(6-Phenyl-imidazo[1,2-a]pyrimidin-7-yl)-benzyl]-piperidin-4-yl}-3H-benzimidazole-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Piperidin-4-yl-1h-benzoimidazole-5-carbonitrile hydrochloride salt | HCID 68752932 | — |
| Reactant | 4-(6-Phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde | HCID 86630655 | — |
| Product | 2-{1-[4-(6-Phenyl-imidazo[1,2-a]pyrimidin-7-yl)-benzyl]-piperidin-4-yl}-3H-benzimidazole-5-carbonitrile | HCID 68753404 | 78.1% |
Reaction Steps
150 mg (0.5 mmol) 4-(6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde described in example 1 and 136 mg (0.6 mmol) 2-piperidine-4-yl-3H-benzimidazole-5-carbonitrile hydrochloride salt were reacted and purified as described in example 6.0. 199 mg of the desired compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08957064B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-594037ab7f85497293cc8836594253fd |
| Source note | uspto-grants-2015_02 |