HRID1851279

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID68752284

未命名化合物

结构：COC(=O)c1cnn2cc(-c3c(F)cccc3F)c(-c3ccc(C=O)cc3)nc12

HCID86703046

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1cnn2cc(-c3c(F)cccc3F)c(-c3ccc(CN4CC(c5n[nH]c(-c6ccccn6)n5)C4)cc3)nc12

HCID178498894

未命名化合物

PROCEDURE

实验过程

The compound is prepared in analogy to example 27.0. 348.5 mg 2-(5-Azetidine-3-yl-[1,2,4]triazole-3-yl)-pyridine×2HCl are reacted with 500 mg (1.27 mmol) 6-(2,6-difluorophenyl)-5-(4-formylphenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid methyl ester. After the usual work-up and purification 254 mg (32.9%) of the title compound are obtained.

WORKUP

后处理

customThe compound is prepared in analogy to example 27.0
customAfter the usual work-up and purification 254 mg (32.9%) of the title compound
customare obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-da56e30bf2c4498491771a92f0b53733
来源数据集: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08957064B2
来源说明: uspto-grants-2015_02

反应 SMILES

[NH:1]1[CH2:4][CH:3]([C:5]2[NH:9][N:8]=[C:7]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=3)[N:6]=2)[CH2:2]1.[CH3:16][O:17][C:18]([C:20]1[CH:21]=[N:22][N:23]2[CH:28]=[C:27]([C:29]3[C:34]([F:35])=[CH:33][CH:32]=[CH:31][C:30]=3[F:36])[C:26]([C:37]3[CH:42]=[CH:41][C:40]([CH:43]=O)=[CH:39][CH:38]=3)=[N:25][C:24]=12)=[O:19]>>[CH3:16][O:17][C:18]([C:20]1[CH:21]=[N:22][N:23]2[CH:28]=[C:27]([C:29]3[C:30]([F:36])=[CH:31][CH:32]=[CH:33][C:34]=3[F:35])[C:26]([C:37]3[CH:38]=[CH:39][C:40]([CH2:43][N:1]4[CH2:4][CH:3]([C:5]5[N:6]=[C:7]([C:10]6[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=6)[NH:8][N:9]=5)[CH2:2]4)=[CH:41][CH:42]=3)=[N:25][C:24]=12)=[O:19]