2-(5-Azetidine-3-yl-[1,2,4]triazole-3-yl)-6-methylpyridine → HCID 178482056, compound

HRID 1851308Notes

Reaction equation

HRID 1851308 reaction equation
[NH:1]1[CH2:4][CH:3]([C:5]2[NH:9][N:8]=[C:7]([C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[N:11]=3)[N:6]=2)[CH2:2]1.[CH3:17][C:18]1[N:19]=[C:20]2[N:25]=[C:24]([C:26]3[CH:33]=[CH:32][C:29]([CH:30]=O)=[CH:28][CH:27]=3)[C:23]([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)=[C:22]([NH:40][CH3:41])[N:21]2[CH:42]=1>>[CH3:41][NH:40][C:22]1[N:21]2[CH:42]=[C:18]([CH3:17])[N:19]=[C:20]2[N:25]=[C:24]([C:26]2[CH:33]=[CH:32][C:29]([CH2:30][N:1]3[CH2:4][CH:3]([C:5]4[N:6]=[C:7]([C:10]5[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[N:11]=5)[NH:8][N:9]=4)[CH2:2]3)=[CH:28][CH:27]=2)[C:23]=1[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1

Participants

3

Reactant 2

HCID 687534852-(5-Azetidine-3-yl-[1,2,4]triazole-3-yl)-6-methylpyridineHCID 867030554-(2-Methyl-5-methylamino-6-phenyl-imidazo[1,2-a]pyrimidin-7-yl)benzaldehyde

Product 1

HCID 178482056HCID 178482056, compound

Procedure

The compound is prepared in analogy to example 60. 416 mg 2-(5-Azetidine-3-yl-[1,2,4]triazole-3-yl)-6-methylpyridine×2HCl (60% pure) are reacted with 270 mg (0.79 mmol) 4-(2-methyl-5-methylamino-6-phenyl-imidazo[1,2-a]pyrimidin-7-yl)benzaldehyde to yield finally after HPLC purification 88.3 mg (20.7%) of the expected compound.

Workup

  1. customThe compound is prepared in analogy to example 60
  2. customto yield finally
  3. customafter HPLC purification 88.3 mg (20.7%) of the expected compound

Sources & evidence

ORD record
ord-472565b50d014178ad0612f563c5cdc9
Source dataset
uspto-grants-2015_02
Patent number
US08957064B2

Reaction notes

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