HRID1851308

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID68753485

未命名化合物

结构：CNc1c(-c2ccccc2)c(-c2ccc(C=O)cc2)nc2nc(C)cn12

HCID86703055

未命名化合物

PRODUCTS

生成物

结构：CNc1c(-c2ccccc2)c(-c2ccc(CN3CC(c4n[nH]c(-c5cccc(C)n5)n4)C3)cc2)nc2nc(C)cn12

HCID178482056

未命名化合物

PROCEDURE

实验过程

The compound is prepared in analogy to example 60. 416 mg 2-(5-Azetidine-3-yl-[1,2,4]triazole-3-yl)-6-methylpyridine×2HCl (60% pure) are reacted with 270 mg (0.79 mmol) 4-(2-methyl-5-methylamino-6-phenyl-imidazo[1,2-a]pyrimidin-7-yl)benzaldehyde to yield finally after HPLC purification 88.3 mg (20.7%) of the expected compound.

WORKUP

后处理

customThe compound is prepared in analogy to example 60
customto yield finally
customafter HPLC purification 88.3 mg (20.7%) of the expected compound

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-472565b50d014178ad0612f563c5cdc9
来源数据集: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08957064B2
来源说明: uspto-grants-2015_02

反应 SMILES

[NH:1]1[CH2:4][CH:3]([C:5]2[NH:9][N:8]=[C:7]([C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[N:11]=3)[N:6]=2)[CH2:2]1.[CH3:17][C:18]1[N:19]=[C:20]2[N:25]=[C:24]([C:26]3[CH:33]=[CH:32][C:29]([CH:30]=O)=[CH:28][CH:27]=3)[C:23]([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)=[C:22]([NH:40][CH3:41])[N:21]2[CH:42]=1>>[CH3:41][NH:40][C:22]1[N:21]2[CH:42]=[C:18]([CH3:17])[N:19]=[C:20]2[N:25]=[C:24]([C:26]2[CH:33]=[CH:32][C:29]([CH2:30][N:1]3[CH2:4][CH:3]([C:5]4[N:6]=[C:7]([C:10]5[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[N:11]=5)[NH:8][N:9]=4)[CH2:2]3)=[CH:28][CH:27]=2)[C:23]=1[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1