反应详情

A mixture of ethyl 1-(methoxymethyl)-7-nitro-1H-indole-2-carboxylate (2.35 g), 10% palladium-carbon (0.24 g), ethanol (4 ml) and tetrahydrofuran (10 ml) was stirred at room temperature overnight under a hydrogen atmosphere. Palladium-carbon was filtered off, and the filtrate was concentrated. The residue was subjected to silica gel column chromatography and the title compound (1.92 g, yield 91%) was obtained as a yellow oil from a fraction eluted with ethyl acetate-hexane (1:3, volume ratio).

1. filtrationPalladium-carbon was filtered off
2. concentrationthe filtrate was concentrated