Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | HCID 178496780 | HCID 178496780 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178496779 | HCID 178496779 | — |
Reaction Steps
A mixture of N-[(1E)-(dimethylamino)methylene]-1-(methoxymethyl)-7-[(methoxymethyl)(2-thienylsulfonyl)amino]-1H-indole-2-carboxamide (1.06 g), hydrazine monohydrate (0.22 mL) and acetic acid (10 mL) was stirred at 80° C. for 1 hr. Water was added to the reaction mixture, and the obtained crystals were filtrated, washed with water and dried to give the title compound (0.99 g, quantitative) as colorless crystals. melting point 97-99° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08957070B2 |
|---|
| Source dataset | uspto-grants-2015_02 |
|---|
| ORD ID | ord-eb9c4a2797864438aba2518cc8fa3430 |
|---|
| Source note | uspto-grants-2015_02 |
|---|
