Acetic Acid → HCID 178496779, compound

HRID 1851362Notes

Reaction equation

HRID 1851362 reaction equation
C[N:2](/[CH:4]=[N:5]/[C:6]([C:8]1[N:9]([CH2:29][O:30][CH3:31])[C:10]2[C:15]([CH:16]=1)=[CH:14][CH:13]=[CH:12][C:11]=2[N:17]([CH2:26][O:27][CH3:28])[S:18]([C:21]1[S:22][CH:23]=[CH:24][CH:25]=1)(=[O:20])=[O:19])=O)C.O.[NH2:33]N.C(O)(=O)C>O>[CH3:28][O:27][CH2:26][N:17]([C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[C:10]=1[N:9]([CH2:29][O:30][CH3:31])[C:8]([C:6]1[N:5]=[CH:4][NH:2][N:33]=1)=[CH:16]2)[S:18]([C:21]1[S:22][CH:23]=[CH:24][CH:25]=1)(=[O:20])=[O:19]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 24654Hydrazine hydrate (1:1)HCID 178496780HCID 178496780, compound

Product 1

HCID 178496779HCID 178496779, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of N-[(1E)-(dimethylamino)methylene]-1-(methoxymethyl)-7-[(methoxymethyl)(2-thienylsulfonyl)amino]-1H-indole-2-carboxamide (1.06 g), hydrazine monohydrate (0.22 mL) and acetic acid (10 mL) was stirred at 80° C. for 1 hr. Water was added to the reaction mixture, and the obtained crystals were filtrated, washed with water and dried to give the title compound (0.99 g, quantitative) as colorless crystals. melting point 97-99° C.

Workup

  1. filtrationthe obtained crystals were filtrated
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-eb9c4a2797864438aba2518cc8fa3430
Source dataset
uspto-grants-2015_02
Patent number
US08957070B2

Reaction notes

Loading…