反应详情

温度

60 °C

A mixture of 6-chloro-7-[methyl(2-thienylsulfonyl)amino]-1H-indole-2-carboxamide (0.70 g), Lawesson's reagent (0.77 g) and tetrahydrofuran (20 mL) was stirred at 60° C. for 2 hr. The reaction mixture was concentrated, toluene was added, and the resulting crystals were filtrated, washed with toluene, and dried to give the title compound (0.60 g, yield 84%) as yellow crystals. melting point 200-201° C.

1. concentrationThe reaction mixture was concentrated
2. additiontoluene was added
3. filtrationthe resulting crystals were filtrated
4. washwashed with toluene
5. customdried