Hydrochloric Acid → HCID 178527469, compound

Participants

Reaction Steps

A mixture of N-(methoxymethyl)-N-[1-(methoxymethyl)-2-(1H-1,2,4-triazol-3-yl)-1H-indol-7-yl]thiophene-2-sulfonamide (0.40 g), concentrated hydrochloride (1 mL) and methanol (10 mL) was heated under reflux for 3 hr. Water was added to the reaction mixture, and the obtained crystals were filtrated, washed with water and dried to give the title compound (0.19 g, yield 60%) as colorless crystals. The crystals were recrystallized from ethyl acetate. melting point>280° C. (decomposition).

Provenance & Evidence