Hydrochloric Acid → HCID 178527469, compound

HRID 1851506Notes

Reaction equation

HRID 1851506 reaction equation
COC[N:4]([C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[C:21]=1[N:20](COC)[C:19]([C:25]1[N:29]=[CH:28][NH:27][N:26]=1)=[CH:18]2)[S:5]([C:8]1[S:9][CH:10]=[CH:11][CH:12]=1)(=[O:7])=[O:6].Cl.CO>O>[NH:27]1[CH:28]=[N:29][C:25]([C:19]2[NH:20][C:21]3[C:17]([CH:18]=2)=[CH:16][CH:15]=[CH:14][C:13]=3[NH:4][S:5]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)(=[O:6])=[O:7])=[N:26]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 178496779HCID 178496779, compound

Product 1

HCID 178527469HCID 178527469, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of N-(methoxymethyl)-N-[1-(methoxymethyl)-2-(1H-1,2,4-triazol-3-yl)-1H-indol-7-yl]thiophene-2-sulfonamide (0.40 g), concentrated hydrochloride (1 mL) and methanol (10 mL) was heated under reflux for 3 hr. Water was added to the reaction mixture, and the obtained crystals were filtrated, washed with water and dried to give the title compound (0.19 g, yield 60%) as colorless crystals. The crystals were recrystallized from ethyl acetate. melting point>280° C. (decomposition).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hr
  3. filtrationthe obtained crystals were filtrated
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-3053c16c98bf411ebaf6bad19fab648d
Source dataset
uspto-grants-2015_02
Patent number
US08957070B2

Reaction notes

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