反应详情

温度

50 °C

A mixture of ethyl 6-chloro-7-[(2-thienylsulfonyl)amino]-1H-indole-2-carboxylate (1.00 g), 4N aqueous sodium hydroxide solution (2.3 mL), tetrahydrofuran (5 mL) and methanol (5 mL) was stirred at 50° C. for 2 hr. The reaction mixture was concentrated and acidified with 10% aqueous citric acid solution. The resulting crystals were filtrated, washed with water, and dried to give the title compound (0.88 g, yield 95%) as colorless crystals. melting point>290° C. (decomposition).

1. concentrationThe reaction mixture was concentrated
2. filtrationThe resulting crystals were filtrated
3. washwashed with water
4. customdried