反应详情

温度

60 °C

A mixture of ethyl 6-chloro-7-[methyl(2-thienylsulfonyl)amino]-1H-indole-2-carboxylate (0.74 g), 4N aqueous sodium hydroxide solution (1.2 mL), tetrahydrofuran (6 mL) and methanol (4 mL) was stirred at 60° C. for 2 hr. The reaction mixture was concentrated and acidified with 10% aqueous citric acid solution. The resulting crystals were filtrated, washed with water, and dried to give the title compound (0.69 g, quantitative) as colorless crystals. melting point 286-288° C.

1. concentrationThe reaction mixture was concentrated
2. filtrationThe resulting crystals were filtrated
3. washwashed with water
4. customdried