Water → HCID 68314109, compound

HRID 1851667Notes

Reaction equation

HRID 1851667 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1.[CH2:12]([NH:19][CH2:20][CH2:21][NH2:22])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.O>C(OCC)(=O)C>[CH3:9][O:8][C:6](=[O:7])[C:5]1[CH:10]=[CH:11][C:2]([NH:22][CH2:21][CH2:20][NH:19][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[N:3][CH:4]=1

Participants

5

Reactant 3

HCID 962WaterHCID 77801N-BenzylethylenediamineHCID 254249Methyl 6-chloropyridine-3-carboxylate

Product 1

HCID 68314109HCID 68314109, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4.6 g of methyl 6-chloronicotinate and 40.5 ml of N-benzylethylenediamine are heated at 135° C. for 6 hours in a round-bottomed flask. The resulting product is poured into water and extraction is carried out with ethyl acetate. The resulting product is dried and evaporated under vacuum; the crude product thus obtained is purified by flash chromatography.

Workup

  1. customThe resulting product is dried
  2. customevaporated under vacuum

Sources & evidence

ORD record
ord-8699b9bd15e1432a8c62cccb5e5b79a3
Source dataset
uspto-grants-2015_02
Patent number
US08957211B2

Reaction notes

Loading…