Sodium sulfate decahydrate → HCID 86720186, compound

Participants

Reaction Conditions

Reaction Steps

2-amino-5,5,5-trifluoropentanenitrile a5 (34 g, 2.2 mol, 1 eq) is dissolved in tetrahydrofurane (290 ml). Lithium aluminium hydride (25.5 g, 6.7 mol, 3 eq) is then added portionwise at 0° C. The reaction mixture is heated at 60° C. for 2 hours, then stirred overnight at room temperature. Disodium sulfate decahydrate (6 eq) is added portionwise and the mixture is stirred until the appearance of a white solid. The precipitate is filtered and the organic phase is condensed under vacuum to afford 11.2 g of 5,5,5-trifluoropentane-1,2-diamine a6 as orange oil.

Provenance & Evidence