Sodium sulfate decahydrate → HCID 86720186, compound

HRID 1851711Notes

Reaction equation

HRID 1851711 reaction equation
[NH2:1][CH:2]([CH2:5][CH2:6][C:7]([F:10])([F:9])[F:8])[C:3]#[N:4].[H-].[Al+3].[Li+].[H-].[H-].[H-].O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+]>O1CCCC1>[F:8][C:7]([F:10])([F:9])[CH2:6][CH2:5][CH:2]([NH2:1])[CH2:3][NH2:4]

Participants

5

Reactant 3

HCID 62649Sodium sulfate decahydrateHCID 21226445Aluminium lithium hydrideHCID 86720185HCID 86720185, compound

Product 1

HCID 86720186HCID 86720186, compoundYield 32%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

2-amino-5,5,5-trifluoropentanenitrile a5 (34 g, 2.2 mol, 1 eq) is dissolved in tetrahydrofurane (290 ml). Lithium aluminium hydride (25.5 g, 6.7 mol, 3 eq) is then added portionwise at 0° C. The reaction mixture is heated at 60° C. for 2 hours, then stirred overnight at room temperature. Disodium sulfate decahydrate (6 eq) is added portionwise and the mixture is stirred until the appearance of a white solid. The precipitate is filtered and the organic phase is condensed under vacuum to afford 11.2 g of 5,5,5-trifluoropentane-1,2-diamine a6 as orange oil.

Workup

  1. stirringthe mixture is stirred until the appearance of a white solid
  2. filtrationThe precipitate is filtered
  3. customcondensed under vacuum

Sources & evidence

ORD record
ord-3a0380ac72d947debef9760be48e61e3
Source dataset
uspto-grants-2015_02
Patent number
US08957218B2

Reaction notes

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