Trifluoroacetic acid → HCID 86720187, compound

HRID 1851712Notes

Reaction equation

HRID 1851712 reaction equation
FC(F)(F)C(O)=O.[O:8]=[C:9]1[N:13](C(OC(C)(C)C)=O)[CH:12]([CH2:21][CH2:22][C:23]([F:26])([F:25])[F:24])[CH2:11][N:10]1C(OC(C)(C)C)=O>ClCCl>[F:26][C:23]([F:24])([F:25])[CH2:22][CH2:21][CH:12]1[CH2:11][NH:10][C:9](=[O:8])[NH:13]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 70980103Di-tert-butyl 2-oxo-4-(3,3,3-trifluoropropyl)imidazolidine-1,3-dicarboxylate

Product 1

HCID 86720187HCID 86720187, compoundYield 131%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Trifluoroacetic acid (6.05 g, 53.04 mmol, 3 eq) in dichloromethane (50 ml) is added to a solution of di-tert-butyl 2-oxo-4-(3,3,3-trifluoropropyl)imidazolidine-1,3-dicarboxylate a7 (6.76 g, 17.68 mmol, 1 eq) in dichloromethane (60 ml) at room temperature overnight. The reaction mixture is condensed under reduced pressure to afford 4.22 g of 4-(3,3,3-trifluoropropyl)imidazolidin-2-one a10 as a yellow oil.

Workup

  1. customcondensed under reduced pressure

Sources & evidence

ORD record
ord-0e917780c832429da0d83b7bacff5a40
Source dataset
uspto-grants-2015_02
Patent number
US08957218B2

Reaction notes

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