反应详情

A solution of potassium carbonate (581 g, 4.20 mol) in water (4 L) is added to a stirred refluxed solution of (H) in methanol (1 L). The mixture is stirred for 18 h, washed with toluene (2×5 L) and acidified to a pH<2 with concentrated HCl (750 mL). The aqueous layer is extracted with ethyl acetate. This organic layer is washed with water, dried over anhydrous MgSO4 and concentrated to give 615 g of (K) (yield=89%)

1. washwashed with toluene (2×5 L)
2. extractionThe aqueous layer is extracted with ethyl acetate
3. washThis organic layer is washed with water
4. dry with materialdried over anhydrous MgSO4
5. concentrationconcentrated