Potassium Carbonate → HCID 58019132, compound

HRID 1851731Notes

Reaction equation

HRID 1851731 reaction equation
C(=O)([O-])[O-].[K+].[K+].C([O:9][C:10]([CH:12]1[CH:16]([CH:17]=[C:18]([F:20])[F:19])[CH2:15][N:14]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][C:23]=2[O:30][CH3:31])[C:13]1=[O:32])=[O:11])C>O.CO>[F:20][C:18]([F:19])=[CH:17][CH:16]1[CH2:15][N:14]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][C:23]=2[O:30][CH3:31])[C:13](=[O:32])[CH:12]1[C:10]([OH:11])=[O:9]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 58019137HCID 58019137, compound

Product 1

HCID 58019132HCID 58019132, compoundYield 89%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of potassium carbonate (581 g, 4.20 mol) in water (4 L) is added to a stirred refluxed solution of (H) in methanol (1 L). The mixture is stirred for 18 h, washed with toluene (2×5 L) and acidified to a pH<2 with concentrated HCl (750 mL). The aqueous layer is extracted with ethyl acetate. This organic layer is washed with water, dried over anhydrous MgSO4 and concentrated to give 615 g of (K) (yield=89%)

Workup

  1. washwashed with toluene (2×5 L)
  2. extractionThe aqueous layer is extracted with ethyl acetate
  3. washThis organic layer is washed with water
  4. dry with materialdried over anhydrous MgSO4
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-259e3b8e5df24793a6ddff79e698dfa3
Source dataset
uspto-grants-2015_02
Patent number
US08957226B2

Reaction notes

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