反应详情

2-(6-Fluoropyridin-3-yl)-6-methoxy-1,3-benzothiazole (0.201 g) and 2 M dimethylamine in THF (5 mL) were heated in a microwave oven at 100° C. for 5 min. Water was added and the precipitated product was filtered off, washed with water and dried in a desicator over P2O5 to yield 0.193 g of the product as a pale beige solid. 1H NMR δ ppm 8.71 (d, 1 H) 8.07 (dd, 1 H) 7.84 (d, 1 H) 7.65 (d, 1 H) 7.08 (dd, 1 H) 6.77 (d, 1 H) 3.84 (s, 3 H) 3.12 (s, 6 H); MS m/z (M+H) 286.

1. filtrationthe precipitated product was filtered off
2. washwashed with water
3. dry with materialdried in a desicator over P2O5