反应详情

0.7 ml of 2N aqueous sodium hydroxide solution was added to a solution of 100 mg (0.25 mmol) of 1-[[[4-[(dimethylamino)methyl]phenyl]carbonyl]amino]cyclohexanecarboxylic acid phenylmethyl ester in 1 ml of tetrahydrofuran, and the mixture was refluxed under heating overnight. After the mixture was neutralized by concentrated hydrochloric acid, the reaction mixture was distilled off under reduced pressure. 3 ml of methylene chloride, 126 mg (1.25 mmol) of triethylamine and 96 mg (0.5 mmol) 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride were added to the residue, the mixture was stirred for 1 hour. The reaction mixture was distilled off under reduced pressure, an aqueous sodium bicarbonate solution was added thereto, and the mixture was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium bicarbonate solution and dried with anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain 52 mg (68%) of the title compound.

1. temperaturethe mixture was refluxed
2. temperatureunder heating overnight
3. distillationthe reaction mixture was distilled off under reduced pressure
4. distillationThe reaction mixture was distilled off under reduced pressure
5. additionan aqueous sodium bicarbonate solution was added
6. extractionthe mixture was extracted with ethyl acetate
7. washThe organic layer was washed with a saturated aqueous sodium bicarbonate solution
8. dry with materialdried with anhydrous sodium sulfate
9. distillationThe solvent was distilled off under reduced pressure