Acetyl chloride → HCID 71075357, compound

HRID 1852036Notes

Reaction equation

HRID 1852036 reaction equation
[CH:1]([C:4]1[CH:5]=[C:6]([C@@H:10]([NH:12][C:13]([C:15]2[CH:16]=[C:17]3[C:21](=[CH:22][CH:23]=2)[N:20]([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=4[S:37](=[O:40])(=[O:39])[NH2:38])=[CH:27][CH:26]=2)[C:19]([CH3:41])=[C:18]3[CH3:42])=[O:14])[CH3:11])[CH:7]=[CH:8][CH:9]=1)([CH3:3])[CH3:2].[C:43](Cl)(=[O:45])[CH3:44]>C(Cl)Cl>[C:43]([NH:38][S:37]([C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=1[C:28]1[CH:29]=[CH:30][C:25]([CH2:24][N:20]2[C:21]3[C:17](=[CH:16][C:15]([C:13]([NH:12][C@H:10]([C:6]4[CH:7]=[CH:8][CH:9]=[C:4]([CH:1]([CH3:3])[CH3:2])[CH:5]=4)[CH3:11])=[O:14])=[CH:23][CH:22]=3)[C:18]([CH3:42])=[C:19]2[CH3:41])=[CH:26][CH:27]=1)(=[O:39])=[O:40])(=[O:45])[CH3:44]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 71074601HCID 71074601, compound

Product 1

HCID 71075357HCID 71075357, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the mixture of (S)—N-(1-(3-isopropylphenyl)ethyl)-2,3-dimethyl-1-((2′-sulfamoyl-[1,1′-biphenyl]-4-yl)methyl)-1H-indole-5-carboxamide (0.058 g, 0.1 mmol) and TEA (0.03 mL, 0.2 mmol) in DCM (0.5 mL) was slowly added acetyl chloride (0.009 g, 0.11 mmol). The mixture was stirred at room temperature for 1 h.

Sources & evidence

ORD record
ord-8ccd641c13db4adba39c5405b4bba3dc
Source dataset
uspto-grants-2015_02
Patent number
US08957093B2

Reaction notes

Loading…