反应详情

A mixture of methyl 2-(cyanomethyl)benzoate (3.50 g, 20 mmol) and sodium methoxide (10 mL, 25% wt in methanol) in 35 mL MeOH was heated to reflux under nitrogen for 3 h. While still hot, the solution was acidified with 1N HCl solution until the green solution turned to yellow color and a lot of white solid precipitated out. After cooling, the precipitated product was collected by filtration, washed with water and dried to yield the desired product 3-methoxyisoquinolin-1(2H)-one as a white solid (2.8 g, 80%). MS: MS m/z 176.1 (M++1).

1. temperaturewas heated
2. temperatureto reflux under nitrogen for 3 h
3. customa lot of white solid precipitated out
4. temperatureAfter cooling
5. filtrationthe precipitated product was collected by filtration
6. washwashed with water
7. customdried