反应详情

温度

120 °C

To a solution of 1,5-dichloroisoquinoline-4-ol (0.5 g, 2.33 mmol) in DBU (1.06 g, 7.01 mmol) was added isopropyl chloride (0.27 g, 3.5 mmol) at room temperature. The reaction vessel (Pressure tube) was sealed and heated at 120° C. for 6 h. The reaction mass was quenched with 1.5 N HCl solution and extracted with ethyl acetate. The combined organic layer was dried over anhydrous Na2SO4 and evaporated under reduced pressure to get crude compound. The crude compound was purified by silica gel chromatography to get desired compound (0.3 g, 50.1%) as pale yellow solid.

1. customThe reaction vessel (Pressure tube) was sealed
2. customThe reaction mass was quenched with 1.5 N HCl solution
3. extractionextracted with ethyl acetate
4. dry with materialThe combined organic layer was dried over anhydrous Na2SO4
5. customevaporated under reduced pressure
6. customto get crude compound
7. customThe crude compound was purified by silica gel chromatography