Hydrochloric Acid → 1-(Methoxymethyl)cyclopropane-1-sulfonamide

HRID 1852290Notes

Reaction equation

HRID 1852290 reaction equation
[CH3:1][O:2][CH2:3][C:4]1([S:7]([NH:10]C(=O)OC(C)(C)C)(=[O:9])=[O:8])[CH2:6][CH2:5]1.Cl>O1CCOCC1>[CH3:1][O:2][CH2:3][C:4]1([S:7]([NH2:10])(=[O:9])=[O:8])[CH2:6][CH2:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20773760HCID 20773760, compound

Product 1

HCID 224992771-(Methoxymethyl)cyclopropane-1-sulfonamideYield 88%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-butyl (1-(methoxymethyl)cyclopropyl)sulfonylcarbamate (2.2 g, 8.29 mmol) was added HCl in 1,4-Dioxane (20 ml, 4M solution) at room temperature. The reaction mass was stirred for 2 hr. The reaction mass was evaporated under reduced pressure to get desired compound (1.2 g, 88%) as white solid. 1H NMR (400 MHz, DMSO): δ ppm 6.68 (br, s, 2H), 3.62 (s, 2H), 3.27 (s, 3H), 1.22-1.09 (m, 2H), 0.96-0.91 (m, 2H).

Workup

  1. customThe reaction mass was evaporated under reduced pressure

Sources & evidence

ORD record
ord-75b15b5c7d3f44ffab96651d6a3d2fb7
Source dataset
uspto-grants-2015_02
Patent number
US08957203B2

Reaction notes

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