Hydrochloric Acid → 1-Ethylcyclopropane-1-sulfonamide

HRID 1852291Notes

Reaction equation

HRID 1852291 reaction equation
[CH2:1]([C:3]1([S:6]([NH:9]C(=O)OC(C)(C)C)(=[O:8])=[O:7])[CH2:5][CH2:4]1)[CH3:2].Cl>O1CCOCC1>[CH2:1]([C:3]1([S:6]([NH2:9])(=[O:8])=[O:7])[CH2:5][CH2:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68950182Tert-butyl (1-ethyl cyclopropyl)sulfonylcarbamate

Product 1

HCID 218898321-Ethylcyclopropane-1-sulfonamideYield 87%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-butyl (1-ethyl cyclopropyl)sulfonylcarbamate (4.8 g, 19.25 mmol) was added HCl in 1,4-Dioxane (20 ml, 4M solution) at room temperature. The reaction mass was stirred for 3 hr. The reaction mass was evaporated under reduced pressure to get desired compound (2.5 g, 87%) as brown semi solid. 1H NMR (400 MHz, DMSO): δ ppm 6.70 (br, s, 2H), 1.85-1.81 (m, 2H), 1.10-1.08 (m, 2H), 0.95 (t, J=8 Hz, 3H), 0.89-0.87 (m, 2H).

Workup

  1. customThe reaction mass was evaporated under reduced pressure

Sources & evidence

ORD record
ord-5feb9d7db82040caab8cb09500aa2a40
Source dataset
uspto-grants-2015_02
Patent number
US08957203B2

Reaction notes

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