Sodium Bicarbonate → HCID 178456285, compound

Participants

Reaction Steps

360 mg (1.05 mmol) 2-(2-Trichloromethyl-1H-benzoimidazole-5-sulfonyl)-ethanol were added to a mixture of 225.4 mg (1.05 equiv.) 1-isopropyl-piperidine-4-ylamine-dihydrochloride and 880 mg (10 equiv.) NaHCO3 in 6 mL THF and 3 mL H2O and stirred vigorously for 2 h at room temperature. The reaction mixture was diluted with dichloromethane and washed with a saturated NaHCO3-solution and brine. The organic layer was dried over MgSO4 and concentrated. The obtained product was pure enough for further reactions.

Provenance & Evidence