Sodium Bicarbonate → HCID 178456285, Verbindung

HRID 18523Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 18523
Cl[C:2](Cl)(Cl)[C:3]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([S:12]([CH2:15][CH2:16][OH:17])(=[O:14])=[O:13])=[CH:11][C:5]=2[N:4]=1.Cl.Cl.[CH:22]([N:25]1[CH2:30][CH2:29][CH:28]([NH2:31])[CH2:27][CH2:26]1)([CH3:24])[CH3:23].C([O-])(O)=[O:33].[Na+]>C1COCC1.O.ClCCl>[CH:22]([N:25]1[CH2:30][CH2:29][CH:28]([NH:31][C:2]([C:3]2[NH:7][C:6]3[CH:8]=[CH:9][C:10]([S:12]([CH2:15][CH2:16][OH:17])(=[O:14])=[O:13])=[CH:11][C:5]=3[N:4]=2)=[O:33])[CH2:27][CH2:26]1)([CH3:24])[CH3:23]

Komponenten

7

Edukt 3

HCID 516892Sodium BicarbonateHCID 177503401-(Propan-2-yl)piperidin-4-amine dihydrochlorideHCID 1785274142-(2-Trichloromethyl-1H-benzoimidazole-5-sulfonyl)-ethanol

Produkt 1

HCID 178456285HCID 178456285, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

360 mg (1.05 mmol) 2-(2-Trichloromethyl-1H-benzoimidazole-5-sulfonyl)-ethanol were added to a mixture of 225.4 mg (1.05 equiv.) 1-isopropyl-piperidine-4-ylamine-dihydrochloride and 880 mg (10 equiv.) NaHCO3 in 6 mL THF and 3 mL H2O and stirred vigorously for 2 h at room temperature. The reaction mixture was diluted with dichloromethane and washed with a saturated NaHCO3-solution and brine. The organic layer was dried over MgSO4 and concentrated. The obtained product was pure enough for further reactions.

Aufarbeitung

  1. washwashed with a saturated NaHCO3-solution and brine
  2. dry with materialThe organic layer was dried over MgSO4
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-ae01edf37fbe4643b0adff01d66754c9
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741341B2

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