Sodium Hydroxide → potassium sodium D-glucarate

HRID 1852316Notes

Reaction equation

HRID 1852316 reaction equation
[OH-].[Na+:2].[O:3]=[C:4]([OH:16])[C@@H:5]([C@H:7]([C@@H:9]([C@@H:11]([C:13]([O-:15])=[O:14])[OH:12])[OH:10])[OH:8])[OH:6].[K+:17]>O>[O:3]=[C:4]([O-:16])[C@@H:5]([C@H:7]([C@@H:9]([C@@H:11]([C:13]([O-:15])=[O:14])[OH:12])[OH:10])[OH:8])[OH:6].[K+:17].[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86593939Potassium hydrogen saccharate

Product 1

HCID 56842416potassium sodium D-glucarate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Aqueous sodium hydroxide solution (33 mL, 6 M) was added to a slurry of monopotassium D-glucarate (50.0 g. 0.201 mol) in water (150 mL) until all of the solid dissolved and a constant pH of 9.7 was reached. The solution was concentrated to a syrup and seeded with the title compound. A solid crystalline cake formed over 24 h. The crystals were isolated by filtration, washed with cold 1:1 ethanol/water (3×15 mL), and dried under reduced pressure to give sodium potassium D-glucarate as colorless crystals (48.2 g, 0.157 mol as the dihydrate, 78.3%).

Workup

  1. dissolutiondissolved
  2. concentrationThe solution was concentrated to a syrup
  3. customA solid crystalline cake formed over 24 h
  4. customThe crystals were isolated by filtration
  5. washwashed with cold 1:1 ethanol/water (3×15 mL)
  6. customdried under reduced pressure

Sources & evidence

ORD record
ord-615598eaa08b49009d2db468acb4f75a
Source dataset
uspto-grants-2015_02
Patent number
US08961813B2

Reaction notes

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