Hydrochloric Acid → Cetirizine

HRID 1852350Notes

Reaction equation

HRID 1852350 reaction equation
Cl.[CH:2]1[CH:3]=[CH:4][C:5]([CH:8]([N:16]2[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][C:26]([OH:28])=[O:27])[CH2:18][CH2:17]2)[C:9]2[CH:10]=[CH:11][C:12]([Cl:15])=[CH:13][CH:14]=2)=[CH:6][CH:7]=1.Cl.Cl>O>[CH:2]1[CH:3]=[CH:4][C:5]([CH:8]([N:16]2[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][C:26]([OH:28])=[O:27])[CH2:18][CH2:17]2)[C:9]2[CH:10]=[CH:11][C:12]([Cl:15])=[CH:13][CH:14]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 55182Cetirizine Hydrochloride

Product 1

HCID 2678Cetirizine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2 HCl IR Beads (drug load: approximately 8% by weight): Cetirizine dihydrochloride (180 g) was slowly added to an aqueous solution (15.7 g of polyvinylpyrrolidone {Povidone K-29/32} in 782.8 g of purified water) and mixed well. 60-80 mesh (177-250 μm) sugar spheres (1,900 g) were spray-coated with the drug-layering formulation in a Glatt fluid bed granulator, GPCG 3 equipped with a bottom spray Wurster insert. The drug containing beads were dried, and a seal coat of Opadry Clear (42.8 g) was applied. The drug load was measured to be 8.4% by weight.

Workup

  1. additionmixed well
  2. customequipped with a bottom spray Wurster insert
  3. additionThe drug containing beads
  4. customwere dried

Sources & evidence

ORD record
ord-fe456dc07ef04b43883abd987d2c4078
Source dataset
uspto-grants-2015_02
Patent number
US08962022B2

Reaction notes

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