反应详情

2 HCl IR Beads (drug load: approximately 8% by weight): Cetirizine dihydrochloride (180 g) was slowly added to an aqueous solution (15.7 g of polyvinylpyrrolidone {Povidone K-29/32} in 782.8 g of purified water) and mixed well. 60-80 mesh (177-250 μm) sugar spheres (1,900 g) were spray-coated with the drug-layering formulation in a Glatt fluid bed granulator, GPCG 3 equipped with a bottom spray Wurster insert. The drug containing beads were dried, and a seal coat of Opadry Clear (42.8 g) was applied. The drug load was measured to be 8.4% by weight.

1. additionmixed well
2. customequipped with a bottom spray Wurster insert
3. additionThe drug containing beads
4. customwere dried