2-Methoxybenzoyl chloride → HCID 67535862, compound

HRID 1852362Notes

Reaction equation

HRID 1852362 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[C:13]([C:16]3[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=3)[NH:14][CH:15]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:24][O:25][C:26]1[CH:34]=[CH:33][CH:32]=[CH:31][C:27]=1[C:28](Cl)=[O:29]>C1(C)C=CC=CC=1>[CH3:24][O:25][C:26]1[CH:34]=[CH:33][CH:32]=[CH:31][C:27]=1[C:28]([C:15]1[NH:14][C:13]([C:16]2[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=2)=[CH:12][C:11]=1[C:8]1[CH:7]=[CH:6][C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])=[CH:10][CH:9]=1)=[O:29]

Participants

4

Reactant 2

HCID 889692-Methoxybenzoyl chlorideHCID 67534335HCID 67534335, compound

Product 1

HCID 67535862HCID 67535862, compoundYield 60.2%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixed solution of 300 mg of 4-(4-tert-butylphenyl)-2-(4-methoxyphenyl)pyrrole, 201 mg of 2-methoxybenzoylchloride, and 10 mL of toluene was heated at 120° C. for 6 hours under a nitrogen flow. After cooling to room temperature, evaporation was performed. After washing with 20 mL of ethanol and vacuum drying, 260 mg of 2-(2-methoxybenzoyl)-3-(4-tert-butylphenyl)-5-(4-methoxyphenyl)pyrrole was obtained.

Workup

  1. customevaporation
  2. washAfter washing with 20 mL of ethanol and vacuum
  3. customdrying

Sources & evidence

ORD record
ord-96f74cfd444e4fa381655dfea04cd7bb
Source dataset
uspto-grants-2015_02
Patent number
US08962155B2

Reaction notes

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