Dimethylformamide → 2-{4-[4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-phenoxy}-2-methyl-propionic acid ethyl ester

HRID 185249Notes

Reaction equation

HRID 185249 reaction equation
[C:38](=[O:39])([O-:40])[O-:41].[CH2:22]([CH3:23])[O:24][C:25]([C:26]([CH3:27])([CH3:28])[O:29][c:30]1[cH:31][cH:32][c:33]([OH:36])[cH:34][cH:35]1)=[O:37].[Cl:1][CH2:2][c:3]1[c:4]([CH:19]2[CH2:20][CH2:21]2)[n:5][c:6](-[c:9]2[cH:10][cH:11][c:12]([C:15]([F:16])([F:17])[F:18])[cH:13][cH:14]2)[n:7][cH:8]1.[Cs+:42].[Cs+:43].[O:44]=[CH:45][N:46]([CH3:47])[CH3:48]>>[CH2:2]([c:3]1[c:4]([CH:19]2[CH2:20][CH2:21]2)[n:5][c:6](-[c:9]2[cH:10][cH:11][c:12]([C:15]([F:16])([F:17])[F:18])[cH:13][cH:14]2)[n:7][cH:8]1)[O:36][c:33]1[cH:32][cH:31][c:30]([O:29][C:26]([C:25]([O:24][CH2:22][CH3:23])=[O:37])([CH3:27])[CH3:28])[cH:35][cH:34]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 181741Ethyl 2-(4-hydroxyphenoxy)-2-methylpropanoateHCID 219359605-Chloromethyl-4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidine

Product 1

HCID 670723982-{4-[4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-phenoxy}-2-methyl-propionic acid ethyl ester

Sources & evidence

ORD record
ord-1c140e5f13a049a4877c50d24ea7baa0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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